Cosmetic Ingredient Review 1620 L Street NW, Suite 1200, Washington, DC 20036- 4702 Final Report Panel Meeting Date:March 17-18, 2014

Safety Assessment of Alkyl Betaines as Used in Cosmetics

ABSTRACT The Cosmetic Ingredient Review Exper t Panel reviewed the product use, formulation and safety data of eleven alkyl  betaines, which mostly function  as hair  and  skin -conditioning agents .  With the exception of betaine, alkyl betaines  may also function as antistatic agents, surfactants -cleansing  agents , and viscosity increasing agents in cosmetic  products . Although  there are data gaps, the shared chemical core structure, similar functions and concentrations in  cosmetics, and the expected similarities in physicochemical  properties, enabled groupi ng these ingredients and  reading across the available toxicological data to support the safety assessment of each individual compound in the  entire group.  The Panel concluded alkyl betaines  were safe as cosmetic ingredients in the present practices of use  and concentration, when formulated to be non- irritating.

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