Int J Toxicol. 2014 Nov-Dec;33(4 Suppl):5S-12S. 2014 Oct 16.
Safety assessment of animal- and plant-derived amino acids as used in cosmetics
Burnett C1, Heldreth B2, Bergfeld WF3, Belsito DV3, Hill RA3, Klaassen CD3, Liebler DC3, Marks JG Jr3, Shank RC3, Slaga TJ3, Snyder PW3, Andersen FA4.
Abstract
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of animal- and plant-derived amino acid mixtures, which function as skin and hair conditioning agents. The safety of α-amino acids as direct food additives has been well established, based on extensive research through acute and chronic dietary exposures and the Panel previously has reviewed the safety of individual α-amino acids in cosmetics. The Panel focused its review on dermal irritation and sensitization data relevant to the use of these ingredients in topical cosmetics. The Panel concluded that these 21 ingredients are safe in the present practices of use and concentration as used in cosmetics.
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The Cosmetic Ingredient Review was established in 1976 by the industry trade association (then the Cosmetic, Toiletry, and Fragrance Association, now the Personal Care Products Council), with the support of the U.S. Food and Drug Administration and the Consumer Federation of America. Although funded by the Council, CIR and the review process are independent from the Council and the cosmetics industry. CIR operates under a set of procedures.
General policy and direction are given by a 7-member Steering Committee chaired by the President and CEO of the Council, with a dermatologist representing the American Academy of Dermatology, a toxicologist representing the Society of Toxicology, a consumer representative representing the Consumer Federation of America, an industry scientist (the current chair of the Council's CIR Committee), Chair of the CIR Expert Panel, and the Council’s Executive Vice President for Science.