-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Natural Products Insider , Octobar 22.2007.
CoQ10 facts or fabrications
William W. Judy , Ph..D., Willis W. Stogsdill . M.D., Daniel S. Judy, M.D. and Janet S Judy RN CRC
Open and download : http://www.zmc- sa.com/docs/CoQ10_Facts_or_Fabrications.pdf
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Biofactors. 2015 Nov 12; 41(6): 383–390.
Published online 2015 Dec 9. doi: 10.1002/biof.1239
Topical treatment with coenzyme Q10 containing formulas improves skin's Q10 level and provides antioxidative effects
Anja Knott, 1 Volker Achterberg, 1 Christoph Smuda, 1 Heiko Mielke, 1 Gabi Sperling, 1 Katja Dunckelmann, 1 Alexandra Vogelsang, 1 Andrea Krüger, 1 Helge Schwengler, 1 Mojgan Behtash, 1 Sonja Kristof, 1 Heike Diekmann, 1 Tanya Eisenberg, 1 Andreas Berroth, 1 Janosch Hildebrand, 1 Ralf Siegner, 1 Marc Winnefeld, 1 Frank Teuber, 1 Sven Fey, 1 Janne Möbius, 1 Dana Retzer, 1 Thorsten Burkhardt, 1 Juliane Lüttke, 1 and Thomas Blatt 1
Abstract
Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid‐soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects. Application of Q10‐containing formulas significantly increased the levels of this quinone on the skin surface. In the deeper layers of the epidermis the ubiquinone level was significantly augmented indicating effective supplementation. Concurrent elevation of ubiquinol levels suggested metabolic transformation of ubiquinone resulting from increased energy metabolism. Incubation of cultured human keratinocytes with Q10 concentrations equivalent to treated skin showed a significant augmentation of energy metabolism. Moreover, the results demonstrated that stressed skin benefits from the topical Q10 treatment by reduction of free radicals and an increase in antioxidant capacity. © 2015 BioFactors, 41(6):383–390, 2015
Open and download : Biofactors. 2015 Nov 12; 41(6): 383–390.
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Latin American Journal of Pharmacy (Acta Farmacéutica Bonaerense)
Lat. Am. J. Pharm. 28 (6): 819-26 (2009)
Original Article Received: February 26, 2009
Development of Semi-Solid Cosmetic Formulations Containing Coenzyme Q10-Loaded Nanocapsules
Open and download : Latin American Journal of Pharmacy 28 (6) : 819-26 (2009)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Cosmetic Science Technology 2006
Preparation and Properties of Coenzyme Q10 Nanoemulsions
Authors: Fred Zülli*, Esther Belser, Daniel Schmid, Christina Liechti and Franz Suter, Mibelle AG Biochemistry, CH
Abstract
Coenzyme Q10 (CoQ10), also known as ubiquinone, is used for energy production within cells and acts as an anti-oxidant. Due to this dual function CoQ10 finds its application in different commercial branches such as drugs, food supplements, or cosmetics. Since CoQ10 is highly lipophilic, the topical and oral bioavailability is very low. Several attempts have been made to improve absorption. Latest technical developments reveal that encapsulation of CoQ10 in nanoemulsions results in a significantly enhanced bioavailability. In addition, multiple nanoemulsions prepared according to a patented process even allow the administration of several incompatible substances at the same time. This article gives an overview of current key developments of the encapsulation of CoQ10 in nanoemulsions. It highlights how encapsulation upgrades the bioavailability of CoQ10 and with this the efficacy of CoQ10. In addition, this article presents latest in vitro tests demonstrating the influence of CoQ10 on the synthesis of collagen I and on the activity of mitochondria and their resistance against stress of dermal fibroblasts and keratinocytes, respectively
Open and download : Properties of Coenzyme Q10 Nanoemulsions
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------