Safety Assessment of Alkyl Esters as Used in Cosmetics.

 Fiume MM¹, Heldreth BA², Bergfeld WF³, Belsito DV³, Hill RA³, Klaassen CD³, Liebler DC³, Marks JG Jr³, Shank RC³, Slaga TJ³, Snyder PW³, Andersen FA⁴.

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 237 alkyl esters for use in cosmetics. The alkyl esters included in this assessment have a variety of reported functions in cosmetics, with skin-conditioning agent being the most common function. The Panel reviewed available animal and clinical data in making its determination of safety on these ingredients, and where there were data gaps, similarity in structure, properties, functions, and uses of these ingredients allowed for extrapolation of the available toxicological data to assess the safety of the entire group. The Panel concluded that these ingredients are safe in cosmetic formulations in the present practices of use and concentration when formulated to be nonirritating.

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