Safety Assessment of Alkyl Esters as Used in Cosmetics.
Fiume MM1, Heldreth BA2, Bergfeld WF3, Belsito DV3, Hill RA3, Klaassen CD3, Liebler DC3, Marks JG Jr3, Shank RC3, Slaga TJ3, Snyder PW3, Andersen FA4.
- 1 Cosmetic Ingredient Review Senior Scientific Analyst/Writer, Washington, DC, WA, USA.
- 2 Cosmetic Ingredient Review Chemist, Washington, DC, USA.
- 3 Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
- 4 Former Director, Cosmetic Ingredient Review, Washington, DC, USA.
Abstract
The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 237 alkyl esters for use in cosmetics. The alkyl esters included in this assessment have a variety of reported functions in cosmetics, with skin-conditioning agent being the most common function. The Panel reviewed available animal and clinical data in making its determination of safety on these ingredients, and where there were data gaps, similarity in structure, properties, functions, and uses of these ingredients allowed for extrapolation of the available toxicological data to assess the safety of the entire group. The Panel concluded that these ingredients are safe in cosmetic formulations in the present practices of use and concentration when formulated to be nonirritating.